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After three weeks of virus expression, the expression and functional impact of the MOR knockdown in PVN Glu neurons were assessed using immunofluorescence staining, western blotting, and ex vivo brain slice electrophysiological recordings

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M1 macrophages, typically activated by IFN-, are characterized by the production of IL-1, TNF-, IL-6, and iNOS, and are closely associated with synovial inflammation and tissue destruction (106)