While this side effect is pretty rare, it can be extremely dangerous when left untreated
However, two medications, Liraglutide and Semaglutide, have been approved for children aged 12 or older
The effects of dual GLP-1/GIP receptor agonism on glucagon secretion-A review
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This microbial shift disrupts multiple gutbrain pathways simultaneously: these shifts coincided with gut barrier disruption (elevated serum endotoxin), triggering elevated hippocampal cytokines (IL-6, TNF-), which in turn suppress Tph2 expression and induce Tph2 hypermethylation (suggesting neuroinflammation and serotonergic suppression), ultimately manifesting as anxiety and depression-like behaviors (Buchenauer et al., 2023)