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Most patients begin noticing reduced appetite and gradual weight loss within the first few weeks of consistent use

Blood pressure lowering effect considering baseline body mass index A pre-specified secondary analysis included baseline BMI as a covariate

The differences within the GLP-1 class are significant enough to affect clinical decision-making

Semaglutide works by slowing gastric emptying and activating GLP-1 receptors in your brain's appetite centers, with peak effects occurring 2472 hours after injection

Treatment starts at the lowest dose and is increased gradually every 4 weeks based on response and tolerability

Semaglutide Side Effects Most commonly, side effects of semaglutide may include: Nausea Vomiting Diarrhea Constipation Stomach discomfort For many, these side effects decrease over time as the body adjusts