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However, a multicenter study in 5,485 subjects with cardiovascular disease or diabetes mellitus showed that daily supplementation with folic acid (2.5 mg), vitamin B 12 (1 mg), and vitamin B6 (50 mg) lowered homocysteine concentrations but had no effect on fracture risk compared to placebo (118)

Always refer to the range listed on your specific report and discuss context with your clinician

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Of the included papers, 16 were randomised control trials (RCT), five were single arm interventional studies, one was a non-randomised comparative interventional study and one was a phase IV clinical trial

Vitamin B12 is an essential component of a number of enzymes involved in normal metabolism

How to take it: Dissolve in mouth or chew 1 lozenge every 3 to 4 days with a meal