Front Immunol (2020) 11:172033
N6-methyladenosine (m 6 A) demethylase FTO is significantly upregulated in MPP + -stimulated SK-N-SH cells, which suppresses YTH domain family protein 2 (YTHDF2) expression, promotes m 6 A demethylation of BRCA1-associated protein 1 (BAP1) and enhances BAP1 expression, upregulates p53 expression, and inhibits SLC7A11 transcription, thereby increasing MDA, Fe 2+ , and 4-HNE levels and triggering neuronal ferroptosis
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Biotechnol Adv 29(6):568574
Emerging evidence indicates that hepatokines, such as fibroblast growth factor (FGF)-21, selenoprotein P (SELENOP), Midbrain astrocyte-derived neurotrophic factor (MANF), Angiopoietin-like protein 3 (ANGPTL3), Fetuin-A, Adropin, ApoJ and sex hormone-binding globulin (SHBG), could regulate oxidative stress, immune responses, and apoptotic pathways, providing new insights into their broader physiological roles [10, 11]
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