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Conclusion As the multi-hit hypothesis holds, combining the therapeutic approaches of GLP-1 agonists with resmetirom seems like a promising strategy by targeting the multifaceted pathophysiology of MASH, which may lead to improved patient outcomes

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Cosentino F, Grant PJ, Aboyans V, Bailey CJ, Ceriello A, Delgado V, et al

Measurement of dNTP pools by RCA-qPCR assay Cells (10 6 ) were extracted with 1 ml of ice-cold 80% methanol for dNTP pool measurement by RCA-qPCR assay as described previously 50