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Not only do these hormones convey signals from the gut to the brain via the gut-brain axis, they also act directly on metabolically important peripheral targets in a highly concerted fashion to maintain energy balance and glucose homeostasis
It is class-wide counter-regulation: stopping removes the signal that was holding down a set-point the body still defends. The felt marker of the rebound is the return of food noise, which patients in the exit interviews reported as the first sign the loss was reversing. Metabolic loss tracks weight regain
pour of their favorite alcoholic beverage or a dessert flight in bite-size pieces or served in shot glasses
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