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organotypic hippocampal slice cultures that maintain an environment representative of an intact hippocampus were employed and evaluated for treatment-induced spinogenesis

Watanabe T, Miyazaki A, Katagiri T, Yamamoto H, Idei T, Iguchi T

In the presence of iron overload, the function of system Xc - is inhibited, leading to a decrease in the synthesis of GSH [36, 37]

Thermostabilizing mutations (green) are S193C, I196F, S225A, M233C, S271A, I317C, G318I, K346A, C347F and G361C