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The authors compared it to insulin: both hormones show an initial surge in hormone levels followed by resistance to the effects of the hormone that outstrips your bodys ability to make more

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The visible before and after results come later, on a timeline that varies by tissue type and indication

Front Cell Neurosci 6:70 Coluccia D, Figuereido C, Isik S, Smith C, Rutka JT (2016) Medulloblastoma: tumor biology and relevance to treatment and prognosis paradigm