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10.1136/bmjopen-2024-095610 83 LiuL.PeritoreC.GinsbergJ.KayhanM.DonmezG

Menstrual disorders are not listed as adverse reactions in UK product information, but any significant disruption warrants clinical assessment

That tends to make drugs like this appear better than they are because as time goes on, you may weed out the people who stop the drug owing to lack of efficacy or to side effects

Eat more highly hydrating foods

The standard recommendation is to initiate treatment with a 20 mg dose administered twice daily, with a maximum approved dosage of 80 mg twice daily