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Manganese is essential part of Mn-SOD enzyme, which reduce the free radicals formation and prevent the mitochondrial membrane from oxidative stress [214]

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In one comparative study of the toxicity of carbon black, single-wall carbon nanotube, silicon dioxide (SiO 2 ), and ZnO NPs, ZnO induced the most remarkable cytotoxicity by promoting intracellular oxidative stress, whereas SiO 2 NPs mainly induced DNA damage (Yang et al., 2009)

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