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A nonexclusive alternative explanation for the kinetic patterns with HEDS (and the decreased enzyme activity at high GSH concentrations) could be a Grx(SSCH 2 CH 2 OH) intermediate that is attacked by GSH according to monothiol mechanism (i) from Fig

In the highest dose group, participants lost up to 28.3% of their body weight over 80 weeks, showing higher efficacy compared to tirzepatide, which led to a 20.9% weight loss at its highest dose in the SURMOUNT-1 trial