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While traditional MCAS treatments can take months to show benefit, I've seen patients experience noticeable improvements in their most troublesome symptoms within 2-4 weeks of starting low-dose GLP-1 therapyexactly aligning with the rapid response times reported in the Afrin study

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But given the commonalities between primates and people, the data indicates it may be time to start human trials. And he stressed that it is very early days still: We first need to establish safety and dosing for humans

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Based on the mixed population samples, a total of 91 valid genetic instruments were included in the MR analysis (Table S3)