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1.8% of diabetic patients taking other medications received a NAION diagnosis

When used for weight loss, its paired with a reduced calorie diet

Case reports have linked GLP-1 agonists like semaglutide to an increased risk, although large studies have shown mixed results

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A 142 -RAGE interaction disrupts tight junctions of the blood-brain barrier via Ca 2+ -calcineurin signaling

Emerging findings indicate that GLP-1 receptor agonists may influence neural and cognitive mechanisms underlying this phenomenon, including reward anticipation and cue reactivity, whereas mindfulness-based interventions appear to act on attentional regulation and aspects of DMN activity relevant to craving and rumination