The initial phase of GLP-1 secretion occurs rapidly, within 1015 minutes of eating, even before nutrients reach the distal intestine where most L-cells reside
Side effects can be mitigated by using lower doses and combining TZD therapy with other medications (SGLT2i and GLP-1 RA) that promote weight loss and sodium excretion [199, 206]
10.1016/j.devcel.2024.06.018 69 LeJ.KonN.LiT.WangS.-J.SuT.HibshooshH.et al (2015)
And when it is hot outside, what happens
Tajan M, Hennequart M, Cheung EC, Zani F, Hock AK, Legrave N, Maddocks ODK, Ridgway RA, Athineos D, Surez-Bonnet A, et al
In ELIXA, the beneficial role of lixisenatide on UACR progression was evident only following statistical adjustments for predisposing factors in patients with baseline MA [12]