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GSSG generated in these processes can be either recycled to GSH by a NADPH-dependent reaction, catalyzed by GR 3 , or pumped out of the cell by ATP-dependent processes, with multidrug resistance-associated protein-1 (MRP-1) being the major pathway for GSSG efflux 33

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they play key roles in the regulation of three physiological processes: Blood coagulation: prothrombin (factor II), factors VII, IX, and X, and proteins C, S, and Z [50] Bone metabolism: osteocalcin, matrix Gla protein (MGP), [51] periostin, [52] and Gla-rich protein

This surface-in pattern strongly suggests that a toxin circulates in the CSF of MS patients to induce myelin damage in the adjacent parenchyma