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ROS Overproduction: The Initiating Driver Hyperglycaemia activates multiple simultaneous ROS sources, including mitochondrial uncoupling, NADPH oxidase isoforms NOX2 and NOX4, and xanthine oxidase upregulation

Changes in brain GSH levels over time were determined as the difference between the GSH/Cr ratio (or absolute GSH) at each time point, relative to baseline

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Interestingly, activation of NRF2 regulates iron-related genes such as FTH1 , FTL1 , SLC40A1 , ABCB6 , and HMOX1 , which in turn promotes the synthesis of GSH synthesis, limits ROS production, and regenerates NADPH [64, 66]

Currently, resveratrol is sold as a nutritional supplement with a wide range of pharmacological effects, including cellular defensive action against oxidative stress [10,11,12]

Liposomal oral formulations offer 50-90% bioavailability with convenient home administration