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To overcome the barriers and to improve the adherence, oral GLP-1 RAs were needed, but oral protein-based drug absorption is limited because of degradation in the stomach due to low pH, proteolytic enzyme activity, and limited permeability across the gastrointestinal (GI) epithelium

Elevated ROS levels lead to lipid peroxidation, resulting in the formation of toxic aldehydes that damage neuronal membranes [179]

Trial Sequential Analysis in systematic reviews with meta-analysis

Stimuli-responsive liposomes have low toxicity and excellent absorption in injured tissues, making them suitable for drug administration [82]

For example, the binding of HSA to polyunsaturated fatty acids and sterols may prevent lipid peroxidation

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