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Figure 1 provides an overview of the molecular mechanisms of potential pathways through which exercise promotes bone metabolism through MOTS-c

It is safe and may be beneficial in COVID-19 due to its anti-inflammatory, immunomodulatory, and antiviral properties that mitigate the SARS-CoV-2induced cytokine storm (133)

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Acknowledgements The authors acknowledge funding from the National Institutes of Health grant (award ID: 1R01CA271304-01)

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The reverse can also be true (drop in capacity while internal resistance remains low)