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The second barrier to an amylin-analog drug was to extend the half-life relative to the first-generation drug, pramlintide, which is injected 3 times daily

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It interacts with neurotransmitter pathways involving serotonin, norepinephrine, and GABA, contributing to its research value in neuroendocrine and circadian rhythm studies

Maintenance dosing schedules are less often than the first doses, usually monthly

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