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Second, rodent models of ageing translate only to a limited degree to humans, especially in telomere biology, which differs markedly between mouse and human
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Additionally, TB-500 is thought to exhibit anti-apoptotic characteristics, observed in cellular models where overexpression of TB-500 appears to increase growth rates, reduce basal apoptosis, and enhance resistance to cell death inducers
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Results demonstrated that -syn aggregation activated ferroptosis, leading to the degeneration of parvalbumin-positive interneurons (PV-INs)
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