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About this article Cite this article El-Ansary, A., Al-Ayadhi, L., Dewedar, A

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Furthermore, therapeutic agents targeting mitochondrial enzymes such as SHMT2, PDH, and CPT1A remain largely in preclinical or early-phase clinical development, with limited data available on optimal delivery strategies, pharmacokinetics, and safety profiles [24]

Instead, these findings provide novel evidence to suggest folate genotypes are selected to maintain homeostasis between de novo thymidylate synthesis and methylation processes at differing UVR levels

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