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By addressing these gaps in research and streamlining therapeutic regimens, probiotics and nutritional synergy can emerge as valuable adjuncts or alternatives to conventional SLE treatments, offering a holistic, personalized, and less toxic approach to disease management

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Key points Metabolomic profiling in patients with systemic lupus erythematosus (SLE) has revealed substantial alterations in amino acid, lipid and energy metabolism, especially linked to oxidative stress and mitochondrial dysfunction, providing valuable indicators of disease activity and severity

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(2016), Indian Dermatology Online Journal , reviewed glutathione's proposed mechanisms and use in skin lightening, noting that while plausible biologically, larger and longer-term trials are still needed