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Most trial protocols used three doses per day with meals

Lkb1 and keap1/nrf2 pathways cooperatively promote metabolic reprogramming with enhanced glutamine dependence in kras-mutant lung adenocarcinoma

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2000;130(5S Suppl):1378S-S1383

[2] High-dose intramuscular administration creates a tissue depot that releases vitamin D slowly over weeks, potentially enabling a single injection to lift serum 25-hydroxyvitamin D levels into the sufficient range in severe deficiency and to potentially support bone mineralisation, neuromuscular function, and secondary hyperparathyroidism reversal while bypassing the gastrointestinal tract