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To enhance translational relevance, recent innovations have integrated PDOs with autologous immune cell or stromal co-culture, and in vivo models such as PDO-derived xenografts (PDXs) and liver metastasis organoid models have been applied for validation

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Then came ACHIEVE-3 , published in The Lancet in February 2026, the first direct head-to-head comparison between two oral GLP-1 therapies

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