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They combined bilirubin and polyethylene glycol into a coupling via a steady amide bond and loaded the anticancer drug doxorubicin (DOX) into BRNPs via film-forming and rehydration to form DOX-loaded BRNPs (DOX@BRNPs)

Laura: Remove the protective seal from a new needle

Do not drink alcohol or smoke for at least 24 hours

But he lost too much weight too fast, to the point where he knew he couldnt continue taking the medication, even at the baseline dose