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The study resulted in more than 50 percent of trial participants losing 15 percent of their body weight, and anywhere between a third and 40 percent of participants losing 20 percent of their body weight

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This is based on the clinical trial design, which used fixed dosing across weight categories

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It has been observed that chronic treatment with KI in rats results in the loss of spermatogenesis, decreased activities of enzymes participating in testosterone production, structural and functional changes of the testis, all these abnormalities being accompanied by the increased oxidative stress [186, 187]

Literature data indicate that PWS patients have lower birth weight and a higher prevalence of preterm delivery and SGA (34)