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Metabolic balance: B12 supports carbohydrate and fat metabolism that NAD+ enhances through coenzyme activity

A separate 2025 narrative review by McGuire and colleagues asked a blunter question in its title: "Regeneration or Risk?" [2] Their conclusion: the preclinical evidence is consistently positive, but the absence of human data makes it impossible to generate evidence-based practice guidelines

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Additional study is necessary to provide a comprehensive understanding of its safety profile and long-term consequences

Pregnant or nursing women should avoid use due to lack of safety data

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