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PA is widespread across all continents and the prevalence of the disease ranges from 50 to 4,000 cases per 100,000 persons, depending on the diagnostic criteria

Comprehensive laboratory monitoring showed no clinically significant changes in hematology, biochemistry, or urinalysis parameters

Researchers originally developed it because they noticed that this particular region of growth hormone seemed responsible for its fat-metabolizing properties, without the growth-promoting or blood sugar effects that make full-length growth hormone problematic for weight management

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All causes for an inadequate response should be addressed before additional agents are added to a patients antihypertensive regimen (Box 12-3)