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Treated female mice that were given DSIP from three months of age until they died, for 5 consecutive days each month, showed a 2.6-fold decrease in tumor development and a 22.6% lower frequency of chromosomal defects in the bone marrow cells

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In a separate study, Zhang et al

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Proc Natl Acad Sci USA 102: 1877318784 Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA (2003) Nrf2 is a direct PERK substrate and effector of PERKdependent cell survival

Phosphorylation of TDP-43 disrupts its nuclear localization, leading to cytoplasmic aggregation (Hasegawa et al., 2008), which has been observed in over 95% of ALS cases (Neumann et al., 2006)