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Connexins enable direct intercellular communication of metabolites, nucleotides, nutrients, and secondary messengers, regulating apoptosis, inflammation, and cellular growth, while also amplifying liver inflammation and cell death (Maes and Vinken 2017

Lucke et al, were the first to in 2004, report diminished activity in respiratory chain complexes using skin fibroblasts from Fabry patients

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This catecholamine-mediated oxidative stress causes aberrant cell signaling, intracellular Ca 2+ overload, mitochondrial damage, inflammatory responses, and disruption of the extracellular matrix and lysosomes, which in turn triggers apoptosis in cardiomyocytes (159163)