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Adverse events caused 12.2% and 18.2% of patients to stop taking the 9 mg and 12 mg doses respectively, compared to 4% stopping placebo

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While different pathophysiological mechanisms have been implicated in the development of chronic constipation, in some instances, the causes of chronic constipation are not easily determined

and Amano, I., 1998

Identification of PDZ5, a candidate universal minicircle sequence binding protein of Trypanosoma cruzi

through unregulated channels