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In fact, it has been shown that the translation of senescence chondrocytes in mice knee joint resulted in OA phenotype, characterized by leg pain, impaired mobility, and radiographic and histological changes (Xu et al., 2017)

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Injectable peptides like BPC-157 and TB-500 typically show initial pain relief within 1-2 weeks, with significant improvement by weeks 4-8

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PMID 36457967