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2), which prevents Ca 2+ -calmodulin binding and activation

For first-time incretin users, tirzepatide offers several advantages: FDA approval, established safety data, pre-filled injection pens (no reconstitution needed), extensive prescriber experience, and lower side effect rates

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Kahn-Krell A, Pretorius D, Guragain B, Lou X, Wei Y, Zhang J, Qiao A, Nakada Y, Kamp TJ, Ye L, Zhang J (2022) A three-dimensional culture system for generating cardiac spheroids composed of cardiomyocytes, endothelial cells, smooth-muscle cells, and cardiac fibroblasts derived from human induced-pluripotent stem cells