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The functionality of claudin-5 may also rely on Rho-associated protein kinase signaling and phosphorylation of the claudin-5 [16]

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A 12-week randomized, double-blind, placebo-controlled study found that a combination of Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 effectively reduced inflammation and alleviated psychiatric symptoms in patients with Major Depressive Disorder (MDD) who were on a gluten-free diet [89]

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