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Risk assessments for human inhalation toxicity based on traditional animal studies generally include a safety factor of 25 to account for uncertainties related to interspecies (animal-to-human: 2.5-safety factor) and inter-individual (human-to-human: 10-safety factor) variabilities (ECHA, 2012)
The copper chelation appears to facilitate cellular uptake through copper transport proteins expressed in keratinocytes and fibroblasts
