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As summarized by Njalsson and Norgren (2005) and Ristoff and Larsson (2007), of the six enzymes in the -glutamyl cycle, diseases have been associated with defects in five of the enzymes, namely -glutamylcysteine ligase, glutathione synthetase, -glutamyl transpeptidase, dipeptidase, and 5-oxoprolinase

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The potent and efficient NRH that serve as an NAD + booster, offers a promising option to increase NAD + levels

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