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Its mostly based on observation, speculation, and experience in the industry

In a Phase IIb study by Steidle et al

Weight loss results vary significantly by specific medication and dose: Semaglutide 2.4 mg (Wegovy): Clinical trials (STEP program) showed average weight reductions of 1517% at 68 weeks Tirzepatide (Zepbound): SURMOUNT trials demonstrated weight reductions of 1522% at 72 weeks, with results varying between populations with and without diabetes Liraglutide 3 mg (Saxenda): Typically produces 510% weight loss over 56 weeks The rate of weight loss is not linear

This has led to a surge of interest in various methods of boosting it, including dietary changes, supplements, and yes, even coffee enemas

You feeling fuller, sooner, means maybe passing on that extra slice of pie

[DOI] [PMC free article] [PubMed] [Google Scholar] Whitworth AJ, Theodore DA, Greene JC, Benes H, Wes PD, Pallanck LJ