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doi: 10.1371/journal.pone.0211185 273 AbcouwerSFShanmugamSMuthusamyALinCMKongDHagerHet al

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Specifically, the accumulation of these electrophilic species up-regulates NF-B-responsive genes, driving the surge of pro-inflammatory cytokines including TNF- , IL-6, and IL-1