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& Barrett, J
Its primary actions include: Inhibiting the reuptake of dopamine and noradrenaline in the central nervous system Minimal effect on serotonin pathways, distinguishing it from most other antidepressants Potential appetite suppression as a secondary effect, though this is not its primary indication Reducing nicotine cravings through dopaminergic pathways Bupropion is metabolised primarily in the liver by the CYP2B6 enzyme system, producing active metabolites
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Your GP or diabetes specialist will assess whether a GLP-1 receptor agonist is suitable based on NICE guidance, typically when metformin and other therapies have not achieved adequate control, or if you have a high BMI, cardiovascular disease, or chronic kidney disease
Hyperglycemia drives the accumulation of advanced glycation end products AGEs, which activate the RAGE/MAPK signaling axis, thereby inhibiting Col-II synthesis and promoting a catabolic state in chondrocytes (31)
Cellular Repair and Regeneration: Helps repair damaged cells and supports the production of new, healthy cells
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