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Notably, the authors suggested that semaglutide may reduce de novo collagen synthesis without causing degradation of pre-existing collagen fibers [29], implying that semaglutide may not improve existing fibrosis, but it may prevent the initiation and progression of fibrosis, which, however, needs other more focused studies to be definitively demonstrated

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Am J Physiol Endocrinol Metab 293(6):E1746E1755

2018;361:k2179

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Avoiding Certain Activities: Refrain from engaging in activities that could potentially irritate or damage the skin, such as swimming in chlorinated pools, using hot tubs, or undergoing other cosmetic treatments, for at least 48 hours post-treatment