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A comparative analysis of clinical efficacy versus social popularity

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Zepbound (tirzepatide) works on two gut hormone receptors (GLP-1 and GIP) instead of one, which may help patients who have plateaued on a single-agonist medication

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He added that GLP-1s like tirzepatide (found in Mounjaro and Zepbound) offer slightly more weight loss with fewer side effects than semaglutide, likely because tirzepatide mimics both GLP-1 and GIP, gut hormones released after eating