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Weeks 1-4: 0.25 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Weeks 5-8: 0.5 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Weeks 9-12: 1.0 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Weeks 13-16: 1.7 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Week 17 and beyond: 2.4 mg semaglutide + 5-10 mg pyridoxine, injected subcutaneously once weekly Some providers modify this schedule based on individual tolerance