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Supported by an increasing number of studies these effects suggest the involvement of IGF-1 in metabolism coordination [136]

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In clinical studies, once-weekly administration of the GLP-1 agonist semaglutide in knee OA patients with obesity reduced patient-reported pain scores (WOMAC) over 68 weeks compared with placebo

Israel Y, Salazar I, Rosenmann E: Inhibitory effects of alcohol on intestinal amino acid transport in vivo and in vitro