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In vivo validation of hits using retroductal injection Based upon drug down selection data and measured EC 50 values, Phenylbutazone, Enoxacin, and Doripenem hydrate were selected for in vivo validation in mice using H2AX foci per nucleus IHC staining as an outcome measure consistent with prior work showing correlation with the development of xerostomia (Supplementary Fig

They may produce abdominal cramps and bloating

They work, and they're well-regulated

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The appetite-suppressing effect is stronger

A SPAC is a shell company that lists publicly with no business of its own, then merges with a private operating company to take it public faster than a traditional initial public offering