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Results In SURPASS, the prevalence of patients meeting the criteria for metabolic syndrome at baseline was 6788% across treatment groups with reductions at the primary endpoint to 3864% with tirzepatide versus 6482% with comparators

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8 suggests a ping-pong kinetic mechanism of OsDHAR, with one ping-pong reaction at the cysteine active site region and one ordered sequential binding site for GSH at H-site 29