This data suggests that CAFs are capable of shifting the metabolism of cancer cells from mitochondrial dependent to glycolytic dependent and upregulating their glutamine metabolism
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aureus and Enterococcus , and are further aggravated by comorbidities like obesity and peripheral arterial disease, leading to prolonged recovery, higher morbidity, and increased healthcare burden ( Streptococcus pneumoniae and influenzaand education on foot hygiene and early infection recognition are critical ( 6 Interactions between metabolic disorders and inflammation Metabolic diseases such as atherosclerosis, diabetes mellitus, obesity, gout, rheumatoid arthritis (RA), osteoporosis, and osteopenia frequently coexist with acute or chronic inflammatory processes ( Figure 2 )
