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Continued efforts resulted in an analog characterized by increased hydrophobicity, decreased hydrogen bonding potential coupled with increased metabolic stability bonding potential, and significantly increased metabolic stability [69,72]

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According to a long-term outcomes study in The Lancet (PubMed) , a significant proportion of patients with chronic sciatica who did not receive surgical intervention continued to report sciatica pain at one and two years, highlighting the importance of timely specialist evaluation