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Further improvements in maternal glucose levels and reductions in complications attributed to maternal hyperglycaemia will require more physiological approaches, including glucose responsive insulin replacement therapy in type 1 diabetes pregnancy [15]

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However, weight loss induced by GLP-1RAs encompasses both fat and lean tissue compartments and could be associated to nutritional deficiencies, raising important questions regarding their impact on skeletal muscle, particularly in individuals at increased risk of sarcopenia [11]

Those with uncontrolled, newly diagnosed, or severe hyperthyroidism should stabilize their thyroid condition first before considering GLP-1 medications

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doi: 10.1016/S0140-6736(21)02188-7 38 DahlDOnishiYNorwoodPHuhRBrayRPatelHet al