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This hypothesis is supported by several studies that have shown supplementation with SAM improves depressive symptoms (104-107)

Of note, while there are often 4 categories of severity for the measures evaluated in this study (i.e., minimal, mild, moderate, and severe), the minimal and mild groups were collapsed due to a small number of participants in each group

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Chem Biodivers 7(4):805838 Kumar DA, Ramu P (2002) Effect of methanolic extract of Benincasa hispida against histamine and acetylcholine induced bronchospasm in guinea pigs

doi:10.1002/oby.70083

Carruthers, K